In newborns, changing parenteral nutrition sets every 48 hours rather than every 24 hours did not increase infusate contamination

A combination of amoxicillin and clavulanate every 12 hours vs every 8 hours for treatment of acute bacterial maxillary sinusitis.

OBJECTIVE To compare the safety and efficacy of a combination of amoxicillin and clavulanate potassium given orally every 12 hours (amoxicillin, 875 mg; clavulanate, 125 mg) with that given every 8 hours (amoxicillin, 500 mg; clavulanate, 125 mg) for the treatment of patients with acute bacterial maxillary sinusitis. DESIGN Multicenter double-blind randomized double-dummy controlled trial. ...

Patient Safety and Efficacy of Metronidazole 1 g Intravenous Every 24 Hours

Rationale for reading fluconazole MICs at 24 hours rather than 48 hours when testing Candida spp. by the CLSI M27-A2 standard method.

We investigated if CLSI M27-A2 Candida species breakpoints for fluconazole MIC are valid when read at 24 h. Analysis of a data set showed good correlation between 48- and 24-h MICs, as well as similar outcomes and pharmacodynamic efficacy parameters, except for isolates in the susceptible dose-dependent category, such as Candida glabrata.

Olanzapine was more effective than lorazepam at 2 hours but not at 24 hours in bipolar mania with acute agitation.

Patients 201 patients >18 years of age (mean age 40 y, 53% men) who had bipolar disorder, mania, or a mixed diagnosis confirmed with the Structured Clinical Interview for DSMIII-R considered by the site physician to have severe agitation requiring injections and who had a total score >14 on the 5 item Positive and Negative Syndrome Scale-Excited Component (PANSS-EC) scale with >1 individual sco...

Predictors of acute admission of more than 48 hours duration

Background When a patient is admitted to an Emergency Department (ED) in the Region of Southern Denmark, estimation is required whether the patient is expected to remain hospitalized for more or less than 48 hours. If the length of stay (LOS) is expected to be less than 48 hours, the patient stays in the ED until discharge. If LOS is expected to exceed 48 hours, the patient is transferred to th...